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Duration: 60 mins
3D bioprinting technology has emerged in the past 15 years as a tool for the generation of human tissues and organs for transplantation and drug testing.
Dr Gentile’s team has developed a technology that uses stem cells isolated from patients together with 3D bioprinters to fabricate heart tissues. In this process, cardiac bioinks are formed by mixing cells with hydrogels that mimic the microenvironment typical of the human heart.
Bioinks are then extruded through the nozzle of a 3D bioprinter that generates viable and functional heart tissues. Currently, 3D bioprinted tissues are used for drug testing and toxicity studies and for disease modelling of heart damage (such as, heart attacks in a Petri dish). Dr Gentile’s team is also testing how to transplant 3D bioprinted heart tissues in a safe way for the regeneration of damaged heart tissues in patients.
Dr Carmine Gentile
Dr Carmine Gentile, PharmD/PhD, FAHA, is a Lecturer within the School of Biomedical Engineering at the University of Technology Sydney (UTS) and leads the Cardiovascular Regeneration Group both at UTS and at the University of Sydney.
Dr Gentile is an internationally recognised expert in the field of 3D bioprinting and stem cell technologies and his more recent studies focus on novel molecular and cellular approaches to treat cardiovascular disease, including myocardial infarction and heart failure. These studies are based on the use of “mini-hearts” he developed as “bioinks” for human heart tissues.
In 2016, he was invited as Visiting Research Fellow at Harvard Medical School, where he worked towards novel in vitro models using mini-hearts to study human heart physiology. His research received media attention and featured on ABC News (2016), ABC Catalyst (2017), Sydney TEDx (2018), Daily Telegraph (2019) and Channel 7News (2020).
Professor Joanne Tipper
Professor Joanne Tipper, is the Head of School, Biomedical Engineering at UTS and Acting Dean of the Graduate Research School at UTS.
Joanne moved into the multidisciplinary research field of medical engineering in the mid 1990s after completing a PhD in skin microbiology. Over the last 25 years she has developed methodologies for isolating wear particles generated by total joint replacements. With over 80 peer reviewed publications her work has contributed to the understanding of implant failure and the development of longer lasting, more reliable devices.
Her areas of interest include using 3D bioprinting to investigate of spinal cord cellular responses to wear products from spinal implants and instrumentation alongside projects investigating neural stem cell and primary neural cell responses to matrix stiffness of novel hydrogel scaffolds for central nervous system repair.
Sydney Science Trail for everyone
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